ea0022p668 | Neuroendocrinology and Pituitary (<emphasis role="italic">Generously supported by Novartis</emphasis>) | ECE2010
Gasco Valentina
, Beccuti Guglielmo
, Rovere Silvia
, Marotta Filippa
, Aimaretti Gianluca
, Maccario Mauro
, Grottoli Silvia
, Ghigo Ezio
GH deficiency (GHD) in adults leads to impairment in body composition and function, as well as to deranged lipoprotein and carbohydrate metabolism implying increased cardiovascular morbidity. The morphologic and metabolic alterations in GHD syndrome are more marked in patients with the most severe GHD, even when evaluated by maximal provocative test such as GHRH + arginine. IGF1 synthesis and secretion are function of the GH status but also of major metabolic factors such as i...